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Ketoprofen (Orudis)
Summary NSAIDs are most effective for mild to moderate pain accompanied by swelling and inflammation. These drugs relieve pain by inhibiting an enzyme in your body called cyclooxygenase. This enzyme makes hormone-like substances called prostaglandins, which are involved in the development of pain and inflammation. NSAIDs are especially helpful for arthritis and pain resulting from muscle sprains, strains, back and neck injuries or cramps. When taken as directed, NSAIDs are generally safe. But if more than the recommended dosage is taken — and sometimes even the recommended dosage — NSAIDs may cause nausea, stomach pain, stomach bleeding or ulcers. Large doses of NSAIDs can lead to kidney problems and fluid retention. Risk increases with age. If you regularly take NSAIDs, talk to your doctor so that he or she can monitor you for side effects. NSAIDs have a so-called ceiling effect, or limit to how much pain they can control. This means that beyond a certain dosage, they don't provide additional benefit. If someone has moderate to severe pain, exceeding the dosage limit may not help relieve the pain. Many NSAIDs require a prescription, but some lower-dose NSAIDs, such as aspirin and ibuprofen, are available over-the-counter.
Ketoprofen is one of the propionic acid class of non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic effects. It acts by inhibiting the body's production of prostaglandin. Ketoprofen was available over-the-counter in the United States in the form of 12.5 mg coated tablets (Orudis KT®), but the product has been discontinued. It is available by prescription as 25, 50, 75, 100, 150, and 200 mg capsules. Ketoprofen also comes in a 2,5% gel for topical application. Brand names in the US are Orudis and Oruvail. It is available in the UK as Ketoflam and Oruvail, and in France as Bi-Profénid. Ketoprofen is generally prescribed for arthritis-related inflammatory pains or severe tooth-aches that result in the inflation of the gum. Ketoprofen should not be used in with other NSAIDs or corticorticeriods, as this increases the risk of GI ulceration. It should also be used with caution with other anticoagulants. It is commonly used with omeprazole, sucralfate, and cimetidine to help protect the GI tract.
Source: Marketdata Enterprises, Inc., Chronic Pain Management Programs: A Market Analysis, Wikipedia, various other sources
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