The Cleveland Clinic Foundation is designated as a regional referral center for reflex sympathetic dystrophy by the national Reflex Sympathetic Dystrophy Syndrome Association. Services usually provided on an outpatient basis include reconditioning exercises, work hardening, counseling, education, biofeedback training, and medication management. If outpatient care does not resolve the problem, more extensive day or inpatient treatment is then recommended.

Day and inpatient programs involve the same therapies, except that day care patients go home or to a local hotel each night, while inpatients spend the night in the hospital. 24-hour care is required for those who are most severely disabled, who need detoxification, or whose depression or medical condition demands closer observation. The usual length of stay is 3.5 weeks.

Follow-up treatment is strongly recommended. The clinic's monthly, free Aftercare Program includes discussion of progress and difficulties, physical therapy "brush ups", practice in assertiveness and stress management, and medication management, as needed.

Treatment by The Pain Management Department involves evaluating the patient’s medical records, and evaluations are performed by the Department’s pain management physician, psychiatrist or behavioral specialist, and physical or occupational therapist. In addition to blood tests and X-rays, other diagnostic tests which may be performed include: